High Value Laboratory Services and SMART SAMPLES with INSTANT DATA
General List of Testing Methods and Biomarkers
All our Products and Services are For Preclinical Research Purposes ONLY!
We can provide you with a Certificate of Analysis for
Truly Healthy Human Donor specimens, screened for over 150 biomarkers.
We can detect the potential presence of diseases such as leukemias, breast, lung, colorectal, pancreatic, liver, prostate cancers, etc. in samples prior to procurement. This in sharp contrast to “normal” samples
that are tested for 4 viral diseases only!
AMONGST THE AVAILABLE TESTS:
Whole genome, exome, exome + mitochondrial sequencing, transcriptome profiling of mRNA, total RNA (mRNAs and non-coding RNA) or small RNAs (e.g., microRNA), 16s rRNA metagenomics analysis.
Diagnostic Tests and Biomarkers:
Flow cytometry
Leukemia/Lymphoma standard panel (27 biomarkers)
CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14(Mo2), CD14(MY4), CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, Cytoplasmic kappa, Cytoplasmic lambda, Myeloperoxidase
Leukemia/Lymphoma extended panel (52 biomarkers)
CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11b, CD11c, CD13, CD14(Mo2), CD14(MY4), CD15, CD16, CD19, CD20, CD23, CD25, CD26, CD30, CD33, CD34, CD38, CD41b, CD45, CD56, CD57, CD64, CD71, CD103, CD117, CD123, CD138, CD200, CD235a, ZAP70, FMC-7, HLA-DR, TCR alpha-beta, TCR gamma-delta, Cytoplasmic CD3, Surface kappa, surface lambda, Cytoplasmic kappa, Cytoplasmic lambda, Myeloperoxidase, HLA-DR, Glycophorin, TdT, bc-l2, CRLF-2
*Additional biomarkers and custom flow cytometry panels for each type of sample malignancy and for other types of cancers are available upon request.
CERTIFICATE OF ANALYSIS FLOW CYTOMETRY EXAMPLE 1
CERTIFICATE OF ANALYSIS FLOW CYTOMETRY EXAMPLE 2
Molecular analysis (ctNAs-NGS)
Any solid malignant neoplasm
Point Mutations (SNVs)(53 Genes)
AKT1,ALK,APC,AR,ARAF,ATM,BRCA1,BRCA2,CCND1,CDH1,CDK4,CDK6,CDK12,CDKN2A,CTNNB1,EGFR,ERBB2,ESR1,FGFR1,FGFR2,FGFR3,GATA3,GNA11,GNAQ,HRAS,IDH1,IDH2,KIT,KRAS,MAP2K1,MAP2K2,MET,MLH1,MTOR,MYCNF1,NFE2L2,NRAS,NTRK1,NTRK3,PDGFRA,PIK3CA,PTEN,RAF1,RET,RHEB,ROS1,SMAD4,SMO,STK11,TERT,TSC1,VHL
Deletion Variants (Indels)(30 Genes)
AKT1,ALK,APC,ATM,BRAF,BRCA1,BRCA2,CDH1,CDK12,CDKN2A,EGFR,ERBB2,ESR1,FGFR2,GATA3,HNF1A,HRAS,KIT,KRAS,MET,MLH1,NF1,PDGFRA,PIK3CA,PTEN,RET,ROS1,STK11,TSC1,VHL
Amplifications(18 Genes)
AR,BRAF,CCND1,CCND2,CCNE1,CDK4,CDK6,EGFR,ERBB2,FGFR1,FGFR2,KIT,KRAS,MET,MYC,PDGFRA,PIK3CA,RAF1
Fusions (13 Genes)
ALK,EGFR, FGFR1, FGFR2,FGFR3,NTRK1, NTRK2, NTRK3, RET,ROS1, BRAF, NRG1, RAF1
Lung, Breast, Hematological cancers
CERTIFICATE OF ANALYSIS NEXT GENERATION SEQUENCING EXAMPLE 1
Genes (77)
ABA1, AKT1, ALK, APC, AR, ARAF, ATM, BRAF, BRCA1, BRCA2, CCND1, CCND2, CDH1, CDK6, CDKN2A, CREBBP, CTNNB1, EGFR, ERBB2, ERCC2, ESR1, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GATA3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KEAP1, KIT, KRAS, MAP2K1, MAP2K2, MAPK1, MED12, MET, MLH1, MTOR, MYC, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PIK3R1, PPP2R1A, PTEN, PTPN11, RAF1, RB1, RET, RHEB, RHOA, RIT1, ROS1, SF3B1, SMAD4, SMO, SPOP, STK11, TERT, TP53, U2AF1, VHL
Fusion ctDNAs (10)
ALK, FGFR2, FGFR3, NTRK1/2/3, PD-L1, RET, ROS1, TMPRSS2
Fusion ctRNAs(36)
ALK, EGFR, AR, BRAF, CTNNB1-PLAG1, ERG, MYB-NFIB, NRG1, NTRK1/2/3, PAX3-FOXO1, PAX8-PPARG, FLI1, MET, ESR1, ETV1/4/5, FGFR1, FGFR2, FGFR3, AXL-MBIP, CLIP1-LTK, DNAJB1-PRKACA, RSPO2, RSPO3, SLC45A3, TFE3, THADA, TMPRSS, ERBB4, RES, RET, SSX1, SSX2
MSI (6)
BAT25, BAT26, NR21, NR24, NR27, MONO27
Breast, Endometrial and Ovarian cancers [Minimum standard panel (24 Genes)]
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, EPCAM, FANCC, FANCM, MLH1, MSH2, MSH6, Mutyh, NF1, PALB2, PMS2, POLD1, PTEN, RAD51C, RAD51D, RECQL, STK11, TP53, CHEK2
Breast cancer extended panel (50 Genes)
AKT1,ALK,APC,AR,ARAF,BRAF,CCND1,CCND2,CCND3,CDK4,CDK6,CHEK2,CTNNB1,DDR2,EGFR,ERBB2,ERBB3,ESR1,FBXW7,FGFR1,FGFR2,FGFR3,FGFR4,FLT3,GNA11,GNAQ,GNAS,HRAS,IDH1,IDH2,KIT,KRAS,MAP2K1,MAP2K2,MET,MTOR,MYC,NRAS,NTRK1,NTRK3,PDGFRA,PIK3CA,PTEN,RAF1,RET,ROS1,SF3B1,SMAD4, SMO, TP53
Breast cancer fusion transcripts (12 transcripts)
ALK, BRAF, ERG, ETV1, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK3, RET, ROS1
Lung cancer NSCLC (38 Genes)
ALK, BRAF, EGFR, ERBB2, RET, KRAS, MET, ROS1, STK11, NTRK1, AKT1, CCND1, CDKN2A, CTNNB1, ESR1, FGFR1, FGFR2, FGFR3, GATA3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, MAP2K1, MYC, NFE2L2, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PPP2R1A, PTEN, TP53, U2AF1
Colorectal cancer (43 Genes)
AKT1,APC,ARID1A,ATM,BAT25,BAT26,BAT34C4,BAT40,BRAF,CTNNB1,EGFR,ERBB2,FBXW7,GNAS,BAT26,KMT2C,KMT2D,KRAS,MET,MLH1,MLH3,MONO27,MSH2,MSH3,MSH6,MTHFR,MYC,NR21,NR22,NR24,MTHFR,NF1,NF2,NOTCH1,NPM1,NRAS,PIK3CA,PMS1,PMS2,POLE,PTEN,PVT1,RNF43,SMAD4,STK11,STK11,VEGFA,ZFHX3
CERTIFICATE OF ANALYSIS NEXT GENERATION SEQUENCING EXAMPLE 2
*Additional gene panels for other types of cancers are available upon request.
